Studies of CD45+ and CD46+ expression on the peripheral blood lymphocyte subsets of the post-COVID patients

The SARS-CoV-2 virus can enter the cells using S1 viral spike (S) protein, not only by binding to ACE2, but also through other cellular receptors. These candidate receptors include CD46, which, like CD45, belongs pan-leukocyte and is expressed on all types of lymphocytes. In turn, infection accompanied damage almost compartments immune system, mainly T purpose study was evaluate expression levels CD45+ CD46+ in various subpopulations lymphocytes patients who had undergone infection.
 72 were examined. Using flow cytometry technique, we determined (panleukocyte marker for lymphocyte gating), CD46+, CD3+ (T lymphocytes), CD3+, CD4+ (helper inducers), CD8+ (cytotoxic T-lymphocytes), CD56+ (TNK cells) CD3-, (natural killers), CD19+ (B CD4+, CD25+ (activated helpers, early activation HLA-DR late lymphocytes). Our studies have shown that a decrease (CD3+) similar its cytotoxic (CD3+, CD8+), TNK CD56+), as well helpers carrying markers CD25+). At same time, most pronounced observed both among total cells. these patients, level B slightly increased. Recent data suggest there no involvement CD46 receptor may affect receptor. Such exposure lead promotion long-COVID (post-COVID) symptoms such thus requiring new approaches correction disorders.